Research

High-Dimensional Directed Network Analysis of Focal Epileptic Seizure

The evolution of directed brain networks from preictal (300 seconds before seizure onset) to postictal phases (300 seconds after seizure onset)

Patient 1
The diamond at electrode G37 is the SOZ identified by expert interpretation of EEG data. Nodes in light blue are the regions that did not belong to any clusters. Nodes in the same other colors (either dark blue, green, pink, red, purple, orange or yellow) denote different identified clusters of regions. All nodes in red color belong to the SOZ cluster. Grey arrows indicate the identified directed connections between regions. Anterioinferior electrodes preceded by an “X” were resected in a previous epilepsy surgery.

Patient 2
The diamonds are the SOZ identified by expert interpretation of EEG data. Nodes in light blue are the regions that did not belong to any clusters. Nodes in the same other colors (either dark blue, green, pink, red, purple, orange or yellow) denote different identified clusters of regions. Arrows indicate the identified directed connections between regions.

Whole-Brain Network Analysis of Massive Neuroimaging Data

The population-mean whole-brain directed networks under the resting state

The nodes in the same color are identified to be in the same module. Black edges represent directed connections between modules that have distinct functions. The directed connections selected have top 1% posterior probabilities. Our method revealed several smaller modules in large functional brain systems, such as the visual and the default mode system. We also discovered that the strongest between-module directed connections are between the auditory and somatosensory-motor modules and between the cingulo-opercular task control and salience modules.